Publications

Selected Recent Publications:

1. Brain-Immune interactions: Implication for Cognitive impairments in Alzheimer's Disease and autoimmune disorders.

Kadam R, Gupta M, Lazarov O, Prabhakar BS. J Leukoc Biol. 2024 Jun 13:qiae134. doi: 10.1093/jleuko/qiae134. Online ahead of print. PMID: 38869088

2. A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.

Lazarov O, Disouky A, Sanborn M, Mostafa M, Sabitha K, Schantz A, Kim N, Pawlowski S, Honer W, Bennett D, Zhou Y, Keene C, Maienschein-Cline M, Rehman J. Res Sq [Preprint]. 2024 May 30:rs.3.rs-4469965. doi: 10.21203/rs.3.rs-4469965/v1. PMID: 38854131 Free PMC article. Preprint.

3. Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease.

Lazarov O, Gupta M, Kumar P, Morrissey Z, Phan T. Prog Neurobiol. 2024 May;236:102601. doi: 10.1016/j.pneurobio.2024.102601. Epub 2024 Apr 1. PMID: 38570083 Free PMC article. Review.

4. Temporal Alterations in White Matter in An App Knock-In Mouse Model of Alzheimer's Disease.

Morrissey ZD, Gao J, Shetti A, Li W, Zhan L, Li W, Fortel I, Saido T, Saito T, Ajilore O, Cologna SM, Lazarov O, Leow AD. eNeuro. 2024 Feb 26;11(2):ENEURO.0496-23.2024. doi: 10.1523/ENEURO.0496-23.2024. Print 2024 Feb. PMID: 38290851 Free PMC article.

5. Caveolin-1 Autonomously Regulates Hippocampal Neurogenesis Via Mitochondrial Dynamics.

Stephen TKL, Cofresi LA, Quiroz E, Owusu-Ansah K, Ibrahim Y, Qualls E, Marshall J, Li W, Shetti A, Bonds JA, Minshall RD, Cologna SM, Lazarov O. bioRxiv [Preprint]. 2023 Sep 24:2023.09.23.558792. doi: 10.1101/2023.09.23.558792. PMID: 37790360 Free PMC article. Preprint.

6. Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance.

Salta E, Lazarov O, Fitzsimons CP, Tanzi R, Lucassen PJ, Choi SH. Cell Stem Cell. 2023 Feb 2;30(2):120-136. doi: 10.1016/j.stem.2023.01.002. PMID: 36736288 Free PMC article. Review.

7. Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes.

Shetti AU, Ramakrishnan A, Romanova L, Li W, Vo K, Volety I, Ratnayake I, Stephen T, Minshall RD, Cologna SM, Lazarov O. Brain. 2023 Jul 3;146(7):3014-3028. doi: 10.1093/brain/awad028. PMID: 36731883 Free PMC article.

8. Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.

Morrissey ZD, Gao J, Zhan L, Li W, Fortel I, Saido T, Saito T, Bakker A, Mackin S, Ajilore O, Lazarov O, Leow AD. Front Aging Neurosci. 2023 Jan 12;14:1085989. doi: 10.3389/fnagi.2022.1085989. eCollection 2022. PMID: 36711209 Free PMC article.

9. Augmenting neurogenesis rescues memory impairments in Alzheimer's disease by restoring the memory-storing neurons.

Mishra R, Phan T, Kumar P, Morrissey Z, Gupta M, Hollands C, Shetti A, Lopez KL, Maienschein-Cline M, Suh H, Hen R, Lazarov O. J Exp Med. 2022 Sep 5;219(9):e20220391. doi: 10.1084/jem.20220391. Epub 2022 Aug 19. PMID: 35984475 Free PMC article.

10. Questioning the evidence for a Janus-faced nature of adult neurogenesis in Alzheimer's disease.

Phan T, Gupta M, Mishra R, Kumar P, Disouky A, Stephen TKL, Rakowiecki K, Lazarov O. Stem Cell Reports. 2021 Jul 13;16(7):1646-1648. doi: 10.1016/j.stemcr.2021.05.006. Epub 2021 May 27. PMID: 34048691 Free PMC article. No abstract available.

11. Adult hippocampal neurogenesis in Alzheimer's disease.

Disouky A, Lazarov O. Prog Mol Biol Transl Sci. 2021;177:137-156. doi: 10.1016/bs.pmbts.2020.09.002. Epub 2020 Oct 16. PMID: 33453939 Free PMC article.

12. Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models.

Bonds JA, Shetti A, Stephen TKL, Bonini MG, Minshall RD, Lazarov O. Sci Rep. 2020 Oct 1;10(1):16368. doi: 10.1038/s41598-020-73401-9. PMID: 33004912 Free PMC article.

13. Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and Alzheimer's disease.

Lazarov O, Minshall RD, Bonini MG. Int Rev Neurobiol. 2020;155:235-269. doi: 10.1016/bs.irn.2020.03.020. PMID: 32854856 Free PMC article. Review.

14. Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis.

Tobin MK, Stephen TKL, Lopez KL, Pergande MR, Bartholomew AM, Cologna SM, Lazarov O. J Am Heart Assoc. 2020 Apr 7;9(7):e013583. doi: 10.1161/JAHA.119.013583. Epub 2020 Mar 24. PMID: 32204666 Free PMC article.

15. Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.

Bonds JA, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O. J Neurosci. 2019 Oct 23;39(43):8576-8583. doi: 10.1523/JNEUROSCI.0730-19.2019. Epub 2019 Sep 16. PMID: 31527120 Free PMC article.

16. Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.

Tobin MK, Musaraca K, Disouky A, Shetti A, Bheri A, Honer WG, Kim N, Dawe RJ, Bennett DA, Arfanakis K, Lazarov O. Cell Stem Cell. 2019 Jun 6;24(6):974-982.e3. doi: 10.1016/j.stem.2019.05.003. Epub 2019 May 23. PMID: 31130513 Free PMC article.

17. Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Al-Shahi Salman R, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222. PMID: 30642436 Free PMC article.

18. CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.

Bartolotti N, Lazarov O. Brain Behav Immun. 2019 May;78:9-20. doi: 10.1016/j.bbi.2019.01.004. Epub 2019 Jan 12. PMID: 30641141 Free PMC article. Review.

19. Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.

Bartolotti N, Disouky A, Kalinski A, Elmann A, Lazarov O. J Alzheimers Dis. 2018;66(4):1425-1435. doi: 10.3233/JAD-180068. PMID: 30400087 Free PMC article.

20. Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.

Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD. Mol Biol Cell. 2018 May 15;29(10):1190-1202. doi: 10.1091/mbc.E17-01-0049. Epub 2018 Mar 22. PMID: 29563255 Free PMC article.

For a full list:

https://pubmed.ncbi.nlm.nih.gov/?term=lazarov%2C+Orly+or+lazarov-spiegler+or+Spiegler%2C+Orly&sort=date