Publications (selected and recent)


  1. Lazarov O*, Marr R: Neurogenesis and Alzheimer’s disease: At the crossroads. Exp Neurol, 223(2):267-81, 2010 [PMID: 19699201].

  2. Demars M, Hu YS, Gadadhar A, Lazarov O*: Impaired neurogenesis is an early event in the etiology of familial Alzheimer’s disease in transgenic mice” J Neurosci Res., 88(10):2103-17, 2010 [PMID: 20209626].

  3. Hu YS, Xu P, Pigino G, Brady ST, Larson J, Lazarov, O*: Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1∆E9 mice. FASEB J 24(6):1667-81, 2010 [PMID: 20086049].

  4. Lazarov O*, Mattson M, Peterson DA, Pimplikar SW, and van Praag H: When Neurogenesis Encounters Aging and Disease, Trends in Neurosciences, 33(12):569-79, 2010 [PMID: 20961627].

  5. Gadadhar A, Marr R, Lazarov O*: Presenilin-1 regulates neural progenitor cell differentiation in the adult brain, J Neurosci, 31(7):2615–2623, 2011 [PMID: 21325529].

  6. Demars M, Lazarov O*: Soluble Amyloid Precursor Protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin, Stem Cell Research & Therapy, 2(4):36, 2011 [PMID: 21878106].

  7. Lazarov O*, Demars M, Zhao KD, Ali H, Grauzas V, Kney A, Larson JR, Impaired survival of neural progenitor cells in the dentate gyrus of adult mice lacking FMRP, Hippocampus, 22(6):1220-4, 2011 [PMID: 22128095].

  8. Little DM, Foxely S, Marta Zamora and Lazarov O*: A preliminary study targeting neuronal pathways activated following environmental enrichment by resting state fMRI, J Alzheimer's disease, 32(1):101-7, 2012 [PMID: 22766734].

  9. Demars DM and Lazarov O*: All in the family: how the APPs regulate neurogenesis, Front Neurosci, 6:81, 2012 [PMID: 22675290].

  10. Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA: Axonal degeneration in Alzheimer’s disease: when signaling abnormalities meet the axonal transport system, Exp Neurol, 246:44-53, 2013 [PMID: 22721767].

  11. Demars DM, Zhao KD and Lazarov O*: Soluble amyloid precursor protein alpha rescues age-linked decline in neural progenitor cell proliferation, Neurobiol. Aging, 34(10):2431-40, 2013 [PMID:23683827].

  12. Hu YS, Nancy L, Pigino, G, Brady ST and Lazarov, O*: Molecular mechanisms of environmental enrichment: Impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling. PLoSONE, 21;8(5), 2013 [PMID: 23700479].

  13. Lazarov O* and Marr R: Of mice and men: Neurogenesis, cognition and Alzheimer’s disease, Frontiers Neurology, 5:43, 2013 [PMID: 23986699].

  14. Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD and Lazarov O*: Neurogenesis and inflammation following ischemic stroke: what is known and where we go from here, Journal of Cerebral Blood Flow & Metabolism, 34(10):1573-84, 2014 [PMID: 25074747].

  15. Bonds J, Kuttner-Hirshler Y, Bartolotti N, Tobin MK, Pizzi M, Marr R and Lazarov O*: Presenilin 1-dependent neurogenesis regulates hippocampal learning and memory, PLoSONE, 2015, In Press.

  16. Bartolotti N, Hu YS and Lazarov O*: Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer’s Disease Mice, J Alz disease, 50(2):477-89, 2015 [PMID: 26682682].

  17. Hollands C and Lazarov O*: Hippocampal neurogenesis: Learning to remember. Prog. Neurobiol, 2016 138-140:1-18 [PMID: 26855369].

  18. Bartolotti N, Bennett DA and Lazarov O*: Reduced pCREB in Alzheimer’s disease prefrontal cortex is reflected in peripheral blood mononuclear cells. Mol Psychiatry, 2016 21(9):1158-66 [PMID: 27480489].

  19. Lamotte G, Shah RC, Lazarov O, Corcos DM. Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions. J Mot Behav. 2017 49(4):365-377 [PMID: 27870597].

  20. Hollands C, Bartolotti N, Lazarov O*. Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms. Front Neurosci. 2016 May 3;10:178. doi: 10.3389/fnins.2016.00178. Review. [PMID: 27199641].

  21. Kuttner-Hirshler Y, Venkatasubramanian PN, Apolinario J, Bonds J, Wyrwicz AM, Lazarov O*. Brain Biomarkers in Familial Alzheimer's disease mouse models. J Alz disease, 2017 60(3):949-958 [PMID: 28922152].

  22. Hollands C, Tobin MK, Hsu M, Musaraca K, Yu TS, Mishra R, Kernie SG, Lazarov O*: Depletion of Adult Neurogenesis Exacerbates Cognitive Deficits in Alzheimer's disease by Compromising Hippocampal Inhibition. Mol Neurodegeneration, 2017 Sep 8; 12(1):64. [PMID: 28886753].

  23. Elmann A, Telerman A, Ofir R, Kashman Y, Lazarov O. β-amyloid cytotoxicity is prevented by natural achillolide A. J Nat Med, 2018 72(3):626-631. [PMID: 29546477].

  24. Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD. Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells. Mol Biol Cell. 2018 15;29(10):1190-1202. [PMID: 29563255].

  25. Bartolotti N., Disouky A., Kalinski A, Elmann A. and Lazarov O*. Phytochemicals from Achillea fragrantissima are modulators of APP metabolism. J Alz disease, 2018 2018;66(4):1425-1435. [PMID: 30400087].

  26. Bartolotti N and Lazarov O*. CREB signals as PBMC-based Biomarkers of cognitive dysfunction: a novel perspective of the brain-immune axis. Brain Behav Immun. 2019 [PMID:30641141].

  27. Sweeny MD et al. Vascular dysfunction- The disregarded partner of Alzheimer’s disease. Alzheimers Dement. 2019 15(1):158-167. [PMID:30642436].

  28. Tobin MK, Musaraca K, Disouky A, Shetti A, and Lazarov O*. Presence of adult hippocampal neurogenesis in aged adults and Alzheimer's disease. Cell Stem Cell, 2019, 24(6):974-982. [PMID:31130513].

PubMed & PubMed




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